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王学清

副教授 博士生导师

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王学清博士,副教授,博士研究生导师

电话:010-82805935, 电子信箱 : wangxq@bjmu.edu.cn

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? ? ? 1989.9-1993.7 北京医科大学药学专业学习,获学士学位。2001.9-2003.7年于北京大学药剂学专业在职学习,获硕士学位。2005.9-2008.7年于中国科学院生物物理研究所在职学习,获博士学位。2011年于奥地利因斯布鲁克大学进修学习三个月。1993.8留校后进入北京医科大学bet365体育下注_bet.365在线体育投注_bet365官方博客从事教学和科研工作,主要承担本科生、研究生的药剂学、生物药剂学与药物动力学的理论课程与实验课程的教学工作。1998年聘为讲师,2009年聘为副教授。

? ? ? 主持或参与多项国家课题和新药制剂开发工作,包括国家自然科学基金面上项目“受体介导的纳米载体在极性上皮细胞的跨膜转运机理研究”(主持)、“新型预活化巯基化聚合物促进蛋白多肽药物跨膜转运机理研究”(主持)、国家自然科学基金-海外及港澳学者合作研究基金“细胞和斑马鱼模型评价纳米制剂的跨膜转运机理和体内过程”(合作主持)、北京市自然科学基金“阿霉素前药自组装纳米粒的构建及其抗肿瘤作用机制研究”(主持)、973计划资助项目“难溶性药物口服纳米制剂的转运机制及临床转化研究”(PI)、“纳米技术改善难溶性药物功效的应用基础研究”(PI)、863计划资助项目“环孢素A纳米粒口服剂型的研究”(参加)、NSF重点资助项目“基于分子靶向给药的肿瘤联合治疗”(参加)、NSF重点资助项目“载体给药系统的分子药剂学”(参加)、科技部“重大新药创制”新制剂与新释药系统技术平台建设项目(参加)、“蚯蚓纤连蛋白酶在乙型肝炎治疗中的基础研究”、一类新药“RS-27 输液剂的研制”等。

? ? ? 已在国内外刊物发表学术论文100余篇,申请专利10余项,多次参编《药剂学》,《生物药剂学与药物动力学》以及执业药师培训的相关教材。2003年获得教育部自然科学奖2等奖(新型纳米给药系统的研究,第五完成人);2009年获得教育部自然科学奖1等奖(抗肿瘤与肿瘤干细胞多药耐药性长循环载药脂质体给药系统的研究,第七完成人);2012年获教育部自然科学一等奖(基于分子靶的新型抗肿瘤分子靶向递送系统研究,第八完成人)。目前担任多个国内外期刊杂志的审稿人。

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主要研究方向

1.????? 纳米技术增加难溶性药物及生物大分子药物跨生物屏障转运的机制;

2.????? 肿瘤微环境响应型纳米药物递送系统的作用机制。

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代表性论文

1. Feiyang Deng, Hua Zhang, Xing Wang, Yuan Zhang, Hongxiang Hu, Siyang Song, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang*, and Qiang Zhang. Transmembrane Pathways and Mechanisms of Rod-like Paclitaxel Nanocrystals through MDCK Polarized Monolayer. ACS Appl. Mater. Interfaces. 2017, 9: 5803-5816.

2. Ye Li, Xiaoning Song, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Xueqing Wang*, Ying Zheng*. Zebrafish: A Visual Model To Evaluate the Biofate of Transferrin Receptor-Targeted 7Peptide-Decorated Coumarin 6 Micelles. ACS Appl. Mater. Interfaces. 2017, 9, 39048-39058.

3. Yujie Shi, Zujin Shi, Suxin Li, Yuan Zhang, Bing He, Dong Peng, Jie Tian, Ming Zhao*, Xueqing Wang*, Qiang Zhang. The interactions of single-wall carbon nanohorns with polar epithelium. International Journal of Nanomedicine. 2017, 12, 4177–4194.

4. Nan Zheng#, Xing Wang#, Yaoqi Wang, Guobing Xu, Hua Zhang, Wenbing Dai, Bing He, Qiang Zhang, Jiafu Ji*, Xueqing Wang*. A sensitive liquid chromatography/electrospray tandem mass spectroscopy method for simultaneous quantification of a disulfide bond doxorubicin conjugation prodrug and activated doxorubicin: Application to cellular pharmacokinetic and catabolism studies. Journal of Chromatography B. 2017, 1065–1066, 96–103.

5. Yang Zhang, Xianhui Chen, Bo Zhao, Hounan Wu, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Gengmei Xing, Qiang Zhang, Xueqing Wang*. Biosafety study and mechanism comparison on two types of silica with different nanostructures. Toxicology Research. 2017, 6, 487–498.

6. Yanan Cui, Suxin Li, Binlong Chen, Bing He, Lan Yuan, Wenbing Dai, Hua Zhang, Xueqing Wang*, and Qiang Zhang*. Serum Free or Not: Two Distinct Recycling Mechanisms Mediated by Alpha v Beta 3 Integrin. Curr Pharm Biotechnol. 2017, 18: 669-676.

7. 宋晓宁, 李 瑞, 张 华, 代文兵, 何 冰, 郑 颖, 张 强, 王学清*。pH 和靶头密度对FcBP 修饰的PEG-PCL 胶束在Caco-2 细胞上摄取与外排的影响。药学学报,2017, 52 (8): 1331-1336.

8. Qin Song, Xing Wang, Yaoqi Wang, Yanqin Liang, Yanxia Zhou, Xiaoning Song, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. Reduction responsive self-assembled nanoparticles based on disulfide-linked drug-drug conjugate with high drug loading and antitumor efficacy. Molecular Pharmaceutics. 2016, 13, 190-201.

9. Qin Song, Xingxing Chuan, Binlong Chen, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang*, and Qiang Zhang. A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells. Drug Delivery. 2016, 23(5):1734-1746.

10.Feiyang Deng, Chao Yu, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang*, Qiang Zhang. The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transportation in rats. Current Drug Delivery. 2016, 13, 105-110.

11.? 李瑞, 宋晓宁, 张华, 代文兵, 何冰, 郑颖, 张强, 王学清*。FRET 技术研究PEG-PCL 胶束跨MDCK 细胞单层转运的完整性。药学学报, 2016, 51 (8): 1316-1324。

12. 串星星,印亚双,王学清*。还原响应型高载药量普朗尼克F127 聚合物胶束的制备。中国药房,2016, 27 (19): 2693-2696。

13.?? Xianhui Chen, Yang Zhang, Lan Yuan, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, Qiang Zhang. The P-glycoprotein inhibitory effect and related mechanisms of thiolated chitosan and its S-protected derivative. RSC Advances. 2015, 5, 104228–104238.

14.Hua Zhang, Hongxiang Hu, Haoran Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang* and Qiang Zhang*. Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis. Nanoscale. 2015, 7, 10790–10800.

15.Hua Zhang, Youyou Zhao, Xueqing Wang*, and Qiang Zhang. Bioavailability of tramadol hydrochloride after administration via different routes in rats. Biopharmaceutics & Drug Disposition. 2014, 35: 525–531.

16.Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang*, and Qiang Zhang. Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)?Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo. Molecular Pharmaceutics. 2014, 11, 3656-3670.

17.Xueqing Wang, Suxin Li, Yujie Shi, Xingxing Chuan, Ji Li, Ting Zhong, Hua Zhang, Wenbing Dai, Bing He, Qing Zhang*.The development of site-specific drug delivery nanocarriers based on receptor mediation. Journal of Controlled Release. 2014, 193: 139-153.

18.Jingkai Lu, Xingxing Chuan, Hua Zhang, Wenbing Dai, Xinglin Wang, Xueqing Wang*, Qiang Zhang*. Free paclitaxel loaded PEGylated-paclitaxel nanoparticles: Preparation and comparison with other paclitaxel systems in vitro and in vivo. International Journal of Pharmaceutics. 2014, 471 (1-2) 525–535.

19.杨建胜,陈显慧,张华,代文兵,王学清*,张强。稳定化巯基化聚合物PAA-Cys-6MNA 的合成与促渗透功能研究。药学学报,2014, 49 (6): 942-948。

20.Chao Yu, Bing He, Meng-Hua Xiong, Hua Zhang, Lan Yuan, Ling Ma, Wen-Bing Dai, Jun Wang, Xing-Lin Wang, Xue-Qing Wang*, Qiang Zhang*, The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cell. Biomaterials. 2013,34 (26): 6284-6298.

21.Bo Zhao, Xue-Qing Wang*, Xiao-You Wang, Hua Zhang, Wen-Bing Dai, Jun Wang, Zhen-Lin Zhong, Hou-Nan Wu*and Qiang Zhang*. Nanotoxicity comparison of four amphiphilic polymeric micelles with similar hydrophilic or hydrophobic structure.Particle and Fibre Toxicology. 2013, 10:47.

22.于超,何冰,张华,代文兵,王学清*,张强。载香豆素6 的PEG-PCL 胶束跨MDCK 极性上皮细胞的转运过程。药学学报,2013, 48 (9): 1484 -1490。

23.赵波,范俣辰,王学清*,代文兵,张 强*,王杏林。iRGD 修饰的阿霉素主动靶向脂质体的细胞毒与抗肿瘤效果评价。药学学报,2013, 48 (3): 417-422。

24.杨爱华,张华,章俊麟,金武,王学清*,张强。维生素A 修饰的阿霉素隐形脂质体对肝星状细胞的靶向性。中国新药杂志,2013, 22 (15): 1797-1801。

25.串星星,王学清*,张强。还原敏感型聚合物胶束在肿瘤靶向药物递送中的应用。中国药学杂志,2013,48 (24): 2069-2075。

26.Wang Xue-Qing, Zhang Qiang. Microemulsions for Drug Solubilization and Delivery [J]. Drug Delivery Strategies for Poorly Water-Soluble Drugs.2012: 287-323.

27.Xueqing Wang, Javed Iqbal, Deni Rahmat, Andreas Bernkop-Schnürch*. Preactivated thiomers: Permeation enhancing properties. International Journal of Pharmaceutics. 2012, 438 (1-2): 217-224.

28.Xue-Qing Wang, Qiang Zhang*. pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics. 2012, 82 (2): 219-229.

29.Xue-qing Wang, Jie-ming Fan, Ya-ou Liu, Bo Zhao, Zeng-rong Jia, Qiang Zhang. Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat. International Journal of Pharmaceutics 2011. 419 (1-2): 339–346.

30.Ya-Ou Liu, Jie-Ming Fan, Xue-Qing Wang*, Qiang Zhang. Preparation of sorafenib selfmicroemulsifying drug delivery system and its relative bioavailability in rats. Journal of Chinese Pharmaceutical Sciences. 2011, 20: 164-170.

31.王学清,张源,潘荣,赫荣乔。蚯蚓纤溶酶口服后在大鼠胃肠道的转运分布特点。中国新药杂志,2010,19(15):1360-1364。

32.Xue-Qing Wang, Lan Chen, Rong Pan, Jing Zhao, Ying Liu, Rong-Qiao He, An earthworm protease cleaving serum fibronectin and decreasing HBeAg in HepG2.2.15 cells. BMC biochemistry. 2008, 9:30 doi:10.1186/1471-2091-9-30.

33.Xue-Qing Wang, Jun-Dong Dai, Hua Zhang, Xuan Zhang,Jian-Cheng Wang, Qiang Zhang*.Absorption mechanism of cyclosporine A loaded pH-sensitive nanoparticles in rats. Journal of Nanoscience and Nanotechnology. 2008, 8: 2422-2431.

34.Xue-qing Wang, Jia Huang, Jun-dong Dai, Tao Zhang, Wan-liang Lu,Hua Zhang, Xuan Zhang, Jian-cheng Wang, Qiang Zhang*. Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid. International Journal of Pharmaceutics.2006, 322: 146-153.

35.Xue-qing Wang, Jun-dong Dai, Zhen Chen, Tao Zhang, Gui-min Xia, Qiang Zhang*. Bioavailability and Pharmacokinetics of Cyclosporine A loaded pH-sensitive nanoparticles for oral administration. Journal of Controlled Release.2004, 97: 421-429.

36.王学清,张涛,贺颖,章亮,张强*。环孢素A聚乳酸纳米粒胶体的制备与大鼠生物利用度的测定。药学学报,2004,39(1):68-71。

37.王学清,戴俊东,张强*,张涛,夏桂民。环孢素A-羟丙甲纤维素酞酸酯纳米粒的大鼠相对生物利用度。药学学报,2004,39(6):463-466。

38.王学清,陈真,戴俊东,张涛,夏桂民,张强*。不同助悬剂对环孢素A 羟丙甲纤维素酞酸酯纳米粒大鼠口服后体内相对生物利用度的影响。北京大学学报(医学版),2004,36(3):305-308。

39.王学清,齐宪荣*,刘明辉。盐酸丁卡因脂质体凝胶的制备与释放度的测定。中国现代应用药学,2003,20(1):37-40。

40.王学清,齐宪荣*,刘跃鹏。盐酸丁卡因脂质体凝胶剂经皮渗透性。北京大学学报医学版,2002,34(4):365-367和375。

41.王学清,齐宪荣*,张强。提高硝酸甘油舌下片稳定性的方法。中华临床医药杂志,2002,3(3):17-19。

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代表性专利

1. 王学清;宋钦;张强;张华;代文兵。一种还原响应型药物偶联物纳米粒的制备及其应用。授权专利号:ZL201510053565.0。授权公告日:2017.9.5。

2. 王学清;串星星;张强;张华;代文兵;宋钦。一种还原响应型聚乙二醇化药物纳米组合物的制备及应用。授权专利号:ZL201410003163.5。授权公告日:2016.9.14。

3. 王学清;刘亚欧;孙佳妮;范洁明;张强。一种供口服或静脉注射用索拉非尼自微乳化给药系统及其制备方法。授权专利号:ZL200910203734.9,授权公告日:2011.06.08。

4. 张强;代文兵;林志强;王学清。难溶性药物凝胶组合物及其制备方法。授权专利号:ZL201310009133.0,授权公告日:2016.5.25。

5.张强,王学清,戴俊东,周田彦,夏桂民,张涛。供口服的纳米粒给药系统。授权专利号ZL02153918.9,授权公告日:2005.12.28。

6.赫荣乔,王学清,陈岚,潘荣,肖蓉。蚯蚓纤连蛋白酶在乙型肝炎治疗中的应用。专利申请号:200810101356.9,授权公告号:CN 101525610 B,授权公告日:2012.1.25。

7. 张强;代文兵;陈斌龙;王学清;张华;刘同舟。靶向肿瘤相关成纤维细胞的脂质体载药系统。专利申请号:201510185154.7。专利申请日:2015.4.17。

8. 张强;代文兵;王兆扬;王学清;张华;黄昌盛。一种单克隆抗体药物的凝胶组合物。专利申请号:201510185504.X。专利申请日:2015.4.17。

9. 张强;刘同舟;代文兵;何冰;王学清;张华;陈斌龙。一种药物白蛋白纳米粒的制备及其应用方法。专利申请号:201610235654.1。专利申请日:2016.4.15。

10. 张强;梁艳琴;代文兵;李苏昕;张华;王学清。一类基于RGD多肽-化疗药物的小分子偶联物及其纳米前药系统。专利申请号:201610274734.8。专利申请日:2016.4.28。

11. 张强;卫备;代文兵;何冰;王学清;张华;袁兰。一种串联细胞模型及其制备方法。专利申请号:201610239200.1。专利申请日:2016.4.18。